Progressive renal toxicity due to ifosfamide.

Sudden death due to the Acetone toxicity

Propanone is a volatile liquid that can be absorbed by ingestion, inhalation, dermal and is distributed throughout the body. In this study, a fatal case involving acetone poisoning, who was worked in the Red Crescent Medical Center is presented. The deceased was found four hours after death. He was a 25-year-old male nurse and not married. There are the history of smoking since four years ago, ...

Renal clearance of ifosfamide.

Nephrotoxicity is an important clinical side effect of the chemotherapeutic agent ifosfamide. This medication is activated by the hepatic cytochrome P450 system with potentially toxic metabolites produced through both ring hydroxylation and chloroethyl side chain oxidation pathways. Using an isolated perfused rat kidney preparation, we examined the possibility that renal metabolism of ifosfamid...

Reduction of Ifosfamide Toxicity Using Dose Fractionation1

the genitouninamy system. Itostamide has been found to produce hemorrhagic cystitis in 40 to 50% of the patients receiving the drug in single high doses (7, 9, ii). This type of toxicity is accompanied by dysunia and frequency. Azo temia also has been observed in patients receiving doses of 150 mg/kg (11). Cardiac toxicity has not been reported with doses of Ifostamide used to date. Because of ...

Progressive meningoencephalitis due to neurosarcoidosis.

Multiple Organ Damage Due to Boric Acid Toxicity

Background: Boric acid (BA) is commonly used as pesticide, disinfectant and wood preservative. Its ingestion can cause serious organ damages resulting in death. Case report: A 19 year old man was found dead with two empty packs of BA tablets in vicinity of his body. On autopsy examination, brownish stains along with right angle of mouth and right nostril were found. Stomach was damaged with hem...